Biogenesis of small RNAs in animals

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Small RNAs of 20-30 nucleotides can target both chromatin and transcripts, and thereby keep both the genome and the transcriptome under extensive surveillance. Recent progress in high-throughput sequencing has uncovered an astounding landscape of small RNAs in eukaryotic cells. Various small RNAs of distinctive characteristics have been found and can be classified into three classes based on their biogenesis mechanism and the type of Argonaute protein that they are associated with: microRNAs (miRNAs), endogenous small interfering RNAs (endo-siRNAs or esiRNAs) and Piwi-interacting RNAs (piRNAs). This Review summarizes our current knowledge of how these intriguing molecules are generated in animal cells
Publisher
NATURE PUBLISHING GROUP
Issue Date
2009-02
Language
English
Article Type
Review
Keywords

PIWI-INTERACTING RNAS; CELL SELF-RENEWAL; ARGONAUTE SILENCING COMPLEX; MEDIATES NUCLEAR EXPORT; NEGATIVE FEEDBACK LOOP; POSTTRANSCRIPTIONAL REGULATION; DROSOPHILA-MELANOGASTER; C-ELEGANS; CAENORHABDITIS-ELEGANS; MICRORNA MATURATION

Citation

NATURE REVIEWS MOLECULAR CELL BIOLOGY, v.10, no.2, pp.126 - 139

ISSN
1471-0072
DOI
10.1038/nrm2632
URI
http://hdl.handle.net/10203/221042
Appears in Collection
MSE-Journal Papers(저널논문)
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