The enemy within: intronic miR-26b represses its host gene, ctdsp2, to regulate neurogenesis

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Differentiation of multipotent stem cells occurs through the highly coordinated control of gene expression. Repressor element 1 (RE1) silencing transcription factor (REST), a master transcriptional regulator in neuronal stem cells, restricts neuronal gene expression. REST activity is context-dependent and is modified by its cofactors, such as Ctdsp2. In this issue of Genes Development, Dill and colleagues (pp. 25-30) report on the microRNA-mediated regulation of neural differentiation. Interestingly, this microRNA is post-transcriptionally regulated and modulates expression of its host gene, ctdsp2.
Publisher
COLD SPRING HARBOR LAB PRESS
Issue Date
2012-01
Language
English
Article Type
Article
Keywords

POSTTRANSCRIPTIONAL REGULATION; MICRORNA BIOGENESIS; REST; TRANSCRIPTION; EXPRESSION; REVEALS; LIN28; IDENTIFICATION; URIDYLATION; RECOGNITION 저자 정보

Citation

GENES DEVELOPMENT, v.26, no.1, pp.6 - 10

ISSN
0890-9369
DOI
10.1101/gad.184416.111
URI
http://hdl.handle.net/10203/221034
Appears in Collection
MSE-Journal Papers(저널논문)
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