Substituent Effects in BODIPY in Live Cell Imaging

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dc.contributor.authorMulay, Sandip V.ko
dc.contributor.authorYudhistira, Teslako
dc.contributor.authorChoi, Minsukko
dc.contributor.authorKim, Youngsamko
dc.contributor.authorKim, Jinjooko
dc.contributor.authorJang, Yoon Jeongko
dc.contributor.authorJon, Sangyongko
dc.contributor.authorChurchill, David G.ko
dc.date.accessioned2017-03-28T06:56:53Z-
dc.date.available2017-03-28T06:56:53Z-
dc.date.created2017-03-02-
dc.date.created2017-03-02-
dc.date.issued2016-12-
dc.identifier.citationCHEMISTRY-AN ASIAN JOURNAL, v.11, no.24, pp.3598 - 3605-
dc.identifier.issn1861-4728-
dc.identifier.urihttp://hdl.handle.net/10203/220977-
dc.description.abstractSmall-molecule organoselenium-based fluorescent probes possess great capacity in understanding biological processes through the detection of various analytes such as reactive oxygen/nitrogen species (ROS/RNS), biothiols (cysteine, homocysteine and glutathione), lipid droplets, etc. Herein, we present how substituents on the BODIPY system play a significant part in the detection of biologically important analytes for in vitro conditions and live cell imaging studies. The fluorescence of the probe was quenched by 2-chloro and 6-phenyl selenium groups; the probe shows high selectivity with NaOCl among other ROS/RNS, and gives a turn-on response. The maximum fluorescence intensity is attained within approximate to 1-2min with a low detection limit (19.6nm), and shows a approximate to 110-fold fluorescence enhancement compared to signals generated for other ROS/RNS. Surprisingly, in live cell experiments, the probe specifically located and accumulated in lipid droplets, and showed a fluorescence turn-on response. We believe this turn-on response occurred because of aggregation-induced emission (AIE), which surprisingly occurred only by introducing one lipophilic mesityl group at the meso position of the BODIPY.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectRATIOMETRIC FLUORESCENT-PROBE-
dc.subjectINDUCED HOCL PRODUCTION-
dc.subjectHYPOCHLOROUS ACID-
dc.subjectLIPID DROPLETS-
dc.subjectCANCER-CELLS-
dc.subjectLIVING CELLS-
dc.subjectTURN-ON-
dc.subjectSELECTIVE DETECTION-
dc.subjectTAP WATER-
dc.subjectRUTHENIUM(II) COMPLEX-
dc.titleSubstituent Effects in BODIPY in Live Cell Imaging-
dc.typeArticle-
dc.identifier.wosid000392511500019-
dc.identifier.scopusid2-s2.0-85006024515-
dc.type.rimsART-
dc.citation.volume11-
dc.citation.issue24-
dc.citation.beginningpage3598-
dc.citation.endingpage3605-
dc.citation.publicationnameCHEMISTRY-AN ASIAN JOURNAL-
dc.identifier.doi10.1002/asia.201601400-
dc.contributor.localauthorJon, Sangyong-
dc.contributor.localauthorChurchill, David G.-
dc.contributor.nonIdAuthorMulay, Sandip V.-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoraggregation induced emission-
dc.subject.keywordAuthorbodipy-
dc.subject.keywordAuthorfluorescent probes-
dc.subject.keywordAuthorhypochlorous acid-
dc.subject.keywordAuthorlipids-
dc.subject.keywordPlusRATIOMETRIC FLUORESCENT-PROBE-
dc.subject.keywordPlusINDUCED HOCL PRODUCTION-
dc.subject.keywordPlusHYPOCHLOROUS ACID-
dc.subject.keywordPlusLIPID DROPLETS-
dc.subject.keywordPlusCANCER-CELLS-
dc.subject.keywordPlusLIVING CELLS-
dc.subject.keywordPlusTURN-ON-
dc.subject.keywordPlusSELECTIVE DETECTION-
dc.subject.keywordPlusTAP WATER-
dc.subject.keywordPlusRUTHENIUM(II) COMPLEX-
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