DC Field | Value | Language |
---|---|---|
dc.contributor.author | Mulay, Sandip V. | ko |
dc.contributor.author | Yudhistira, Tesla | ko |
dc.contributor.author | Choi, Minsuk | ko |
dc.contributor.author | Kim, Youngsam | ko |
dc.contributor.author | Kim, Jinjoo | ko |
dc.contributor.author | Jang, Yoon Jeong | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Churchill, David G. | ko |
dc.date.accessioned | 2017-03-28T06:56:53Z | - |
dc.date.available | 2017-03-28T06:56:53Z | - |
dc.date.created | 2017-03-02 | - |
dc.date.created | 2017-03-02 | - |
dc.date.issued | 2016-12 | - |
dc.identifier.citation | CHEMISTRY-AN ASIAN JOURNAL, v.11, no.24, pp.3598 - 3605 | - |
dc.identifier.issn | 1861-4728 | - |
dc.identifier.uri | http://hdl.handle.net/10203/220977 | - |
dc.description.abstract | Small-molecule organoselenium-based fluorescent probes possess great capacity in understanding biological processes through the detection of various analytes such as reactive oxygen/nitrogen species (ROS/RNS), biothiols (cysteine, homocysteine and glutathione), lipid droplets, etc. Herein, we present how substituents on the BODIPY system play a significant part in the detection of biologically important analytes for in vitro conditions and live cell imaging studies. The fluorescence of the probe was quenched by 2-chloro and 6-phenyl selenium groups; the probe shows high selectivity with NaOCl among other ROS/RNS, and gives a turn-on response. The maximum fluorescence intensity is attained within approximate to 1-2min with a low detection limit (19.6nm), and shows a approximate to 110-fold fluorescence enhancement compared to signals generated for other ROS/RNS. Surprisingly, in live cell experiments, the probe specifically located and accumulated in lipid droplets, and showed a fluorescence turn-on response. We believe this turn-on response occurred because of aggregation-induced emission (AIE), which surprisingly occurred only by introducing one lipophilic mesityl group at the meso position of the BODIPY. | - |
dc.language | English | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | RATIOMETRIC FLUORESCENT-PROBE | - |
dc.subject | INDUCED HOCL PRODUCTION | - |
dc.subject | HYPOCHLOROUS ACID | - |
dc.subject | LIPID DROPLETS | - |
dc.subject | CANCER-CELLS | - |
dc.subject | LIVING CELLS | - |
dc.subject | TURN-ON | - |
dc.subject | SELECTIVE DETECTION | - |
dc.subject | TAP WATER | - |
dc.subject | RUTHENIUM(II) COMPLEX | - |
dc.title | Substituent Effects in BODIPY in Live Cell Imaging | - |
dc.type | Article | - |
dc.identifier.wosid | 000392511500019 | - |
dc.identifier.scopusid | 2-s2.0-85006024515 | - |
dc.type.rims | ART | - |
dc.citation.volume | 11 | - |
dc.citation.issue | 24 | - |
dc.citation.beginningpage | 3598 | - |
dc.citation.endingpage | 3605 | - |
dc.citation.publicationname | CHEMISTRY-AN ASIAN JOURNAL | - |
dc.identifier.doi | 10.1002/asia.201601400 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.localauthor | Churchill, David G. | - |
dc.contributor.nonIdAuthor | Mulay, Sandip V. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | aggregation induced emission | - |
dc.subject.keywordAuthor | bodipy | - |
dc.subject.keywordAuthor | fluorescent probes | - |
dc.subject.keywordAuthor | hypochlorous acid | - |
dc.subject.keywordAuthor | lipids | - |
dc.subject.keywordPlus | RATIOMETRIC FLUORESCENT-PROBE | - |
dc.subject.keywordPlus | INDUCED HOCL PRODUCTION | - |
dc.subject.keywordPlus | HYPOCHLOROUS ACID | - |
dc.subject.keywordPlus | LIPID DROPLETS | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | LIVING CELLS | - |
dc.subject.keywordPlus | TURN-ON | - |
dc.subject.keywordPlus | SELECTIVE DETECTION | - |
dc.subject.keywordPlus | TAP WATER | - |
dc.subject.keywordPlus | RUTHENIUM(II) COMPLEX | - |
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