Microdroplet-based Cell Culture Models and Their Application

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Microfluidic systems offer precisely controlled experimental conditions for efficient study of mammalian cells, ranged from a single cell to matrix Based three-dimensional (3D) in vitro culture models. Droplet-based microfluidic system is a robust and highly reproducible device enabling encapsulation of a cell or cells within well-confined microenvironment. Recently, such droplet-based cell culture models have drawn much attention due to their unique properties such that conventional culture systems couldn't provide. The encapsulation of cells in specifically designed aqueous phase of a microfluidic system can provide profound understand of cell to cell and cell to extracellular matrix interactions, also can be used to regulate various cell behaviors. A droplet-based cell culture system allows better control over confinement for culturing, maintaining, and analyzing cells, such as high-throughput screening. In this review, we discuss recent researches on microdroplet-based 3D cell culture models, and advanced applications of microfluidic systems.
Publisher
KOREAN BIOCHIP SOCIETY-KBCS
Issue Date
2016-12
Language
English
Article Type
Review
Keywords

DROPLET-BASED MICROFLUIDICS; MESENCHYMAL STEM-CELLS; MULTICELLULAR SPHEROIDS; MICROENGINEERED HYDROGELS; ECM INTERACTIONS; SINGLE-CELLS; CANCER-CELLS; DEVICE; DIFFERENTIATION; ENCAPSULATION

Citation

BIOCHIP JOURNAL, v.10, no.4, pp.310 - 317

ISSN
1976-0280
DOI
10.1007/s13206-016-0407-1
URI
http://hdl.handle.net/10203/220177
Appears in Collection
BiS-Journal Papers(저널논문)
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