Synaptic Actin Dysregulation, a Convergent Mechanism of Mental Disorders?

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Actin polymerization governs activity-dependent modulation of excitatory synapses, including their morphology and functionality. It is clear from humangenetics that neuropsychiatric and neurodevelopmental disturbances are multigenetic in nature, highlighting the need to better understand the critical neural pathways associated with these disorders and how they are altered by genetic risk alleles. One such signaling pathway that is heavily implicated by candidate genes for psychiatric and neurodevelopmental disorders are regulators of signaling to the actin cytoskeleton, suggesting that its disruption and the ensuring abnormalities of spine structures and postsynaptic complexes is a commonly affected pathway in brain disorders. This review will discuss recent experimental findings that strongly support genetic evidence linking the synaptic cytoskeleton to mental disorders, such as schizophrenia and autism spectrum disorders.
Publisher
SOC NEUROSCIENCE
Issue Date
2016-11
Language
English
Article Type
Article
Keywords

POSTSYNAPTIC DENSITY PROTEINS; DENDRITIC SPINE DENSITY; AUTISM SPECTRUM DISORDERS; INSULIN-RECEPTOR SUBSTRATE; CORTICAL PYRAMIDAL NEURONS; LONG-TERM POTENTIATION; FRAGILE-X-SYNDROME; PREFRONTAL CORTEX; BRAIN-DEVELOPMENT; CULTURED NEURONS

Citation

JOURNAL OF NEUROSCIENCE, v.36, no.45, pp.11411 - 11417

ISSN
0270-6474
DOI
10.1523/JNEUROSCI.2360-16.2016
URI
http://hdl.handle.net/10203/219632
Appears in Collection
BS-Journal Papers(저널논문)
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