Immunogenicity of MenACWY-CRM in Korean Military Recruits: Influence of Tetanus-Diphtheria Toxoid Vaccination on the Vaccine Response to MenACWY-CRM

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The quadrivalent meningococcal conjugate vaccine (MenACWY-CRM) has been introduced for military recruits in Korea since 2012. This study was performed to evaluate the immunogenicity of MenACWY-CRM in Korean military recruits. In addition, the influence of tetanus-diphtheria toxoids (Td) vaccination on the vaccine response to MenACWY-CRM was analyzed. A total of 75 military recruits were enrolled. Among them, 18 received a dose of MenACWY-CRM only (group 1), and 57 received Td three days before MenACWY-CRM immunization (group 2). The immunogenicity of MenACWY-CRM was compared between the two groups. The serum bactericidal activity with baby rabbit complement was measured before and three weeks after immunization against serogroups A, C, W-135, and Y. The geometric mean titers (GMTs) against four serogroups were significantly increased in both groups after immunization. Compared to group 2, group 1 exhibited significantly higher vaccine responses in several aspects: post-immune GMTs against serogroup A and C, seroresponse rates against serogroup A, and a fold increases of titers against serogroup A, C, and Y. MenACWY-CRM was immunogenic against all vaccine-serogroups in Korean military recruits. Vaccine response to MenACWY-CRM was influenced by Td administered three days earlier.
Publisher
YONSEI UNIV COLLEGE MEDICINE
Issue Date
2016-11
Language
English
Article Type
Article
Keywords

MENINGOCOCCAL GLYCOCONJUGATE VACCINE; C CONJUGATE VACCINES; NEISSERIA-MENINGITIDIS; YOUNG-ADULTS; ADOLESCENTS; DISEASE; PROTECTION; CHILDREN; SAFETY; SURVEILLANCE

Citation

YONSEI MEDICAL JOURNAL, v.57, no.6, pp.1511 - 1516

ISSN
0513-5796
DOI
10.3349/ymj.2016.57.6.1511
URI
http://hdl.handle.net/10203/218225
Appears in Collection
MSE-Journal Papers(저널논문)
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