Soluble Neuregulin-1 from Microglia Enhances Amyloid Beta-induced Neuronal Death

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 247
  • Download : 0
Neuregulin-1 (NRG-1) is a ligand of the epidermal growth factor receptor (erbB), and its interaction involves activation of the glutamatergic N-methyl-D-aspartate receptor, which increases the expression of the beta 2 subunit of the gamma-aminobutyric acid receptor and subunits of the nicotinic acetylcholine receptor. In the dentate gyrus of 14-month-old Tg2576 mice, NRG-1 was strongly expressed compared with age-matched controls. The supernatant of oligomeric amyloid beta peptide (A beta(42))-treated glial cells enhanced the A beta(42)-induced cytotoxic effects, but the expression of Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand in microglial cells was not changed upon cytotoxic treatment. This suggests that the oligomeric form of A beta(42) toxicity is not related to apoptosis, which is mediated by cell-to-cell interaction. During the 24-h incubation, the secretion of the soluble form of NRG-1 was increased, but interleukin 6 secretion was not changed. Further, soluble NRG-1 increased A beta(42)-induced toxicity. In conclusion, soluble NRG-1 significantly enhanced oligomeric A beta(42)-induced toxicity through the activation of endoplasmic reticulum stress by the increase of a phospho-translation initiation factor 2 alpha (p-eIF2 alpha)
Publisher
BENTHAM SCIENCE PUBL LTD
Issue Date
2016
Language
English
Article Type
Article
Keywords

GLIAL GROWTH-FACTOR; ADULT HUMAN BRAIN; ALZHEIMERS-DISEASE; SCHWANN-CELLS; PRECURSOR PROTEIN; TYROSINE KINASE; ERBB4 RECEPTOR; RAT-BRAIN; IN-VITRO; EXPRESSION

Citation

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, v.15, no.8, pp.918 - 926

ISSN
1871-5273
DOI
10.2174/1871527315666160815160505
URI
http://hdl.handle.net/10203/214855
Appears in Collection
CH-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0