Collaborative effects of wavefront shaping and optical clearing agent in optical coherence tomography

We demonstrate that simultaneous application of optical clearing agents (OCAs) and complex wavefront shaping in optical coherence tomography (OCT) can provide significant enhancement of penetration depth and imaging quality. OCA reduces optical inhomogeneity of a highly scattering sample, and the wavefront shaping of illumination light controls multiple scattering, resulting in an enhancement of the penetration depth and signal-to-noise ratio. A tissue phantom study shows that concurrent applications of OCA and wavefront shaping successfully operate in OCT imaging. The penetration depth enhancement is further demonstrated for ex vivo mouse ears, revealing hidden structures inaccessible with conventional OCT imaging.
Publisher
SPIE spie@spie.org
Issue Date
2016-12
Language
ENG
Citation

Journal of Biomedical Optics, v.21, no.12

ISSN
1083-3668
DOI
10.1117/1.JBO.21.12.121510
URI
http://hdl.handle.net/10203/214788
Appears in Collection
BiS-Journal Papers(저널논문)PH-Journal Papers(저널논문)
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