Dehydrosulfurative C-N Cross-Coupling and Concomitant Oxidative Dehydrogenation for One-Step Synthesis of 2-Aryl(alkyl)aminopyrimidines from 3,4-Dihydropyrimidin-1H-2-thiones

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A method for the synthesis of 2-aryl(alkyl)-aminopyrimidines from readily available 3,4-dihydropyrimidin-1H-2-thiones (DHPMs) via dehydrosulfurative C-N cross coupling and concomitant oxidative dehydrogenation under a Pd/Cu catalytic system is described. This reaction protocol provides unprecedented diversity of fully substituted 2-aryl(alkyl)aminopyrimidines in a single step from a wide range of DHPMs and amine coupling partners
Publisher
AMER CHEMICAL SOC
Issue Date
2016-10
Language
English
Article Type
Article
Keywords

CARBON BOND FORMATION; PYRIMIDIN-2-YL SULFONATES; BIOLOGICAL-ACTIVITY; EFFICIENT APPROACH; CYCLIC THIOAMIDES; CARBOXYLIC-ACIDS; ARYL SULFIDES; BORONIC ACIDS; INHIBITORS; CONVERSION

Citation

ORGANIC LETTERS, v.18, no.19, pp.5154 - 5157

ISSN
1523-7060
DOI
10.1021/acs.orglett.6b02617
URI
http://hdl.handle.net/10203/214108
Appears in Collection
CH-Journal Papers(저널논문)
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