Recent advances in mass spectrometry-based proteomics of gastric cancer

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The last decade has witnessed remarkable technological advances in mass spectrometry-based proteomics. The development of proteomics techniques has enabled the reliable analysis of complex proteomes, leading to the identification and quantification of thousands of proteins in gastric cancer cells, tissues, and sera. This quantitative information has been used to profile the anomalies in gastric cancer and provide insights into the pathogenic mechanism of the disease. In this review, we mainly focus on the advances in mass spectrometry and quantitative proteomics that were achieved in the last five years and how these up-and-coming technologies are employed to track biochemical changes in gastric cancer cells. We conclude by presenting a perspective on quantitative proteomics and its future applications in the clinic and translational gastric cancer research.
Publisher
BAISHIDENG PUBL GRP CO LTD
Issue Date
2016-10
Language
English
Article Type
Article
Keywords

COMPLEX PROTEIN MIXTURES; QUANTITATIVE-ANALYSIS; POTENTIAL BIOMARKER; CLINICAL PROTEOMICS; SHOTGUN PROTEOMICS; BREAST-CANCER; IDENTIFICATION; SECRETOME; CELLS; PHOSPHOPROTEOMICS

Citation

WORLD JOURNAL OF GASTROENTEROLOGY, v.22, no.37, pp.8283 - 8293

ISSN
1007-9327
DOI
10.3748/wjg.v22.i35.0000
URI
http://hdl.handle.net/10203/213933
Appears in Collection
BS-Journal Papers(저널논문)
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