A well-established e-health strategy at the national level is necessary to successfully achieve the trust-and-consensus- based e-health goals by linking strategic information planning and the execution of an implementation plan. This paper provides a methodology of how to establish a national e-health strategy and the case of e-Health Information Strategic Planning (ISP) of the Ministry of Health and Welfare of Korea. The ISP is to improve the quality of care and contribute to the economic growth by integrating a variety of policies and providing affordable and competitive services.