DC Field | Value | Language |
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dc.contributor.author | Lee, Heung Kyu | - |
dc.date.accessioned | 2016-10-13T08:48:19Z | - |
dc.date.available | 2016-10-13T08:48:19Z | - |
dc.date.created | 2016-10-05 | - |
dc.date.issued | 2016-09-08 | - |
dc.identifier.citation | The 15th Awaji International Forum on Infection and Immunity | - |
dc.identifier.uri | http://hdl.handle.net/10203/213404 | - |
dc.description.abstract | Commensal microbiota are well known to play an important role in antiviral immunity by providing immune inductive signals; however, the consequence of dysbiosis on antiviral immunity remains unclear. We demonstrate that dysbiosis caused by oral antibiotic treatment directly impairs antiviral immunity following viral infection of the vaginal mucosa. Antibiotic-treated mice succumbed to mucosal herpes simplex virus type 2 infection more rapidly than water-fed mice, and also showed delayed viral clearance at the site of infection. However, innate immune responses including type I interferon and proinflammatory cytokine production at infection sites, as well as induction of virus-specific CD4 and CD8 T cell responses in draining lymph nodes, were not impaired in antibiotic-treated mice. By screening the factors controlling antiviral immunity, we found that interleukin-33, an alarmin released in response to tissue damage, was secreted from vaginal epithelium after the depletion of commensal microbiota. This cytokine suppresses local antiviral immunity by blocking the migration of effector T cells to the vaginal tissue, thereby inhibiting the production of interferon-γ, a critical cytokine for antiviral defense, at local infection sites. These findings provide insight into the mechanisms of homeostasis maintained by commensal bacteria, and reveal a deleterious consequence of dysbiosis in antiviral immune defense. | - |
dc.language | English | - |
dc.publisher | Awaji Forum Organizing Committee | - |
dc.title | Dysbiosis-induced IL-33 contributes to impaired antiviral immunity in the genital mucosa | - |
dc.type | Conference | - |
dc.type.rims | CONF | - |
dc.citation.publicationname | The 15th Awaji International Forum on Infection and Immunity | - |
dc.identifier.conferencecountry | JA | - |
dc.identifier.conferencelocation | Awaji Yumebutai International Conference Center, Japan | - |
dc.contributor.localauthor | Lee, Heung Kyu | - |
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