Evaluations of the impact resistance of a dry storage cask under mechanical impact loadings resulting from a large commercial aircraft crash have become an important issue for designers and evaluators, in order to promote interim dry storage activities and to evaluate design safety margins. This study presents a method to evaluate the structural integrity of a generic metal cask subjected to various mechanical loading conditions, which represent aircraft engine impacts, on different locations of the cask body. Thirty representative impact conditions are analyzed to provide a comprehensive evaluation of cask damage response. The applied engine impact load time functions were carefully re-derived by utilizing CRIEPI's proposed curve through Riera's approach for six impact velocities, and applied to five locations on a freestanding cask: lateral impacts on the lower half, center of gravity, and upper half of the cask body, corner impact on the lid closure, and vertical impact on the center of the lid closure. A nonlinear dynamic finite element analysis is performed to evaluate the dynamic response of the cask lid closure system and to calculate the lid gaps. The release fractions from the cask to the environment for each impact condition are preliminarily estimated by referring to a proposed methodology from literature. It is believed that this paper presents a systematic process to connect the mechanical analysis of a cask response at the moment of aircraft engine impact with its radiological consequence analysis. (C) 2016 Elsevier B.V. All rights reserved.