DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Peter J. | ko |
dc.contributor.author | Song, Chaeyeon | ko |
dc.contributor.author | Deek, Joanna | ko |
dc.contributor.author | Miller, Herbert P. | ko |
dc.contributor.author | Li, Youli | ko |
dc.contributor.author | Choi, Myung-Chul | ko |
dc.contributor.author | Wilson, Leslie | ko |
dc.contributor.author | Feinstein, Stuart C. | ko |
dc.contributor.author | Safinya, Cyrus R. | ko |
dc.date.accessioned | 2016-09-07T04:23:18Z | - |
dc.date.available | 2016-09-07T04:23:18Z | - |
dc.date.created | 2016-08-29 | - |
dc.date.created | 2016-08-29 | - |
dc.date.issued | 2016-07 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.7, no.12, pp.278 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/212873 | - |
dc.description.abstract | Tau, an intrinsically disordered protein confined to neuronal axons, binds to and regulates microtubule dynamics. Although there have been observations of string-like microtubule fascicles in the axon initial segment (AIS) and hexagonal bundles in neurite-like processes in non-neuronal cells overexpressing Tau, cell-free reconstitutions have not replicated either geometry. Here we map out the energy landscape of Tau-mediated, GTP-dependent 'active' microtubule bundles at 37 degrees C, as revealed by synchrotron SAXS and TEM. Widely spaced bundles (wall-to-wall distance Dw-w approximate to 25-41 nm) with hexagonal and string-like symmetry are observed, the latter mimicking bundles found in the AIS. A second energy minimum (Dw-w approximate to 16-23 nm) is revealed under osmotic pressure. The wide spacing results from a balance between repulsive forces, due to Tau's projection domain (PD), and a stabilizing sum of transient sub-k(B)T cationic/anionic charge-charge attractions mediated by weakly penetrating opposing PDs. This landscape would be significantly affected by charge-altering modifications of Tau associated with neurodegeneration | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | X-RAY-SCATTERING | - |
dc.subject | PROTEIN-TAU | - |
dc.subject | ALZHEIMER-DISEASE | - |
dc.subject | AQUEOUS-SOLUTIONS | - |
dc.subject | TUBULIN | - |
dc.subject | DOMAINS | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | POLYMERIZATION | - |
dc.subject | CONFORMATION | - |
dc.subject | ORGANIZATION | - |
dc.title | Tau mediates microtubule bundle architectures mimicking fascicles of microtubules found in the axon initial segment | - |
dc.type | Article | - |
dc.identifier.wosid | 000380199400001 | - |
dc.identifier.scopusid | 2-s2.0-84979608041 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 278 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms12278 | - |
dc.contributor.localauthor | Choi, Myung-Chul | - |
dc.contributor.nonIdAuthor | Chung, Peter J. | - |
dc.contributor.nonIdAuthor | Song, Chaeyeon | - |
dc.contributor.nonIdAuthor | Deek, Joanna | - |
dc.contributor.nonIdAuthor | Miller, Herbert P. | - |
dc.contributor.nonIdAuthor | Li, Youli | - |
dc.contributor.nonIdAuthor | Wilson, Leslie | - |
dc.contributor.nonIdAuthor | Feinstein, Stuart C. | - |
dc.contributor.nonIdAuthor | Safinya, Cyrus R. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | X-RAY-SCATTERING | - |
dc.subject.keywordPlus | PROTEIN-TAU | - |
dc.subject.keywordPlus | ALZHEIMER-DISEASE | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
dc.subject.keywordPlus | TUBULIN | - |
dc.subject.keywordPlus | DOMAINS | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | POLYMERIZATION | - |
dc.subject.keywordPlus | CONFORMATION | - |
dc.subject.keywordPlus | ORGANIZATION | - |
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