Both H4K20 mono-methylation and H3K56 acetylation mark transcription-dependent histone turnover in fission yeast

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dc.contributor.authorYang, Hannako
dc.contributor.authorKwon, Chang Seobko
dc.contributor.authorChoi, Yoonjungko
dc.contributor.authorLee, Daeyoupko
dc.date.accessioned2016-09-07T01:41:54Z-
dc.date.available2016-09-07T01:41:54Z-
dc.date.created2016-08-16-
dc.date.created2016-08-16-
dc.date.issued2016-08-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.476, no.4, pp.515 - 521-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/212548-
dc.description.abstractNucleosome dynamics facilitated by histone turnover is required for transcription as well as DNA replication and repair. Histone turnover is often associated with various histone modifications such as H3K56 acetylation (H3K56Ac), H3K36 methylation (H3K36me), and H4K20 methylation (H4K20me). In order to correlate histone modifications and transcription-dependent histone turnover, we performed genome wide analyses for euchromatic regions in G2/M-arrested fission yeast The results show that transcription-dependent histone turnover at 5' promoter and 3' termination regions is directly correlated with the occurrence of H3K56Ac and H4K20 mono-methylation (H4K20me1) in actively transcribed genes. Furthermore, the increase of H3K56Ac and H4K20me1 and antisense RNA production was observed in the absence of the histone H3K36 methyltransferase Sett and histone deacetylase complex (HDAC) that are involved in the suppression of histone turnover within the coding regions. These results together indicate that H4K20me1 as well as H3K56Ac are bona fide marks for transcription-dependent histone turnover in fission yeast. (C) 2016 Elsevier Inc. All rights reserved-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectRNA-POLYMERASE-II-
dc.subjectCHROMATIN-STRUCTURE-
dc.subjectNUCLEOSOME-
dc.subjectREPLICATION-
dc.subjectEXCHANGE-
dc.subjectGENES-
dc.subjectH3-
dc.subjectSUPPRESSION-
dc.subjectELONGATION-
dc.subjectSTABILITY-
dc.titleBoth H4K20 mono-methylation and H3K56 acetylation mark transcription-dependent histone turnover in fission yeast-
dc.typeArticle-
dc.identifier.wosid000379886500052-
dc.identifier.scopusid2-s2.0-84975709433-
dc.type.rimsART-
dc.citation.volume476-
dc.citation.issue4-
dc.citation.beginningpage515-
dc.citation.endingpage521-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2016.05.155-
dc.contributor.localauthorLee, Daeyoup-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorHistone turnover-
dc.subject.keywordAuthorHistone turnover marker-
dc.subject.keywordAuthorH3K56Ac-
dc.subject.keywordAuthorH4K20me1-
dc.subject.keywordAuthorSchizosaccharomyces pombe-
dc.subject.keywordPlusRNA-POLYMERASE-II-
dc.subject.keywordPlusCHROMATIN-STRUCTURE-
dc.subject.keywordPlusNUCLEOSOME-
dc.subject.keywordPlusREPLICATION-
dc.subject.keywordPlusEXCHANGE-
dc.subject.keywordPlusGENES-
dc.subject.keywordPlusH3-
dc.subject.keywordPlusSUPPRESSION-
dc.subject.keywordPlusELONGATION-
dc.subject.keywordPlusSTABILITY-
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