On-chip generation of monodisperse giant unilamellar lipid vesicles containing quantum dots

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Monodispersed lipid vesicles have been used as a drug delivery vehicle and a biochemical reactor. To generate monodispersed lipid vesicles in the nano-to micrometer size range, an extrusion step should be included in conventional hand-shaking method of lipid vesicle synthesis. In addition, lipid vesicles as a drug carrier still need to be improved to effectively encapsulate concentrated biomolecules such as cells, proteins, and target drugs. To overcome these limitations, this paper reports a new microfluidic platform for continuous synthesis of small-sized (similar to 10 mu m) giant unilamellar vesicles (GUVs) containing quantum dots (QDs) as a nanosized model drug. To generate GUVs, we introduced an additional cross-flow to break vesicles into small size. 1,2 - dimyristoyl-sn-glycero - 3 - phosphocholine (DMPC) in an octanol-chloroform mixture was used in the construction of self-assembled membrane. Consequently, we have successfully demonstrated the fabrication of monodispersed GUVs with 7-12 mu m diameter containing QDs. The proposed synthesis method of cell-sized GUVs would be highly desirable for applications such as multipurpose drug encapsulation and delivery
Publisher
WILEY-BLACKWELL
Issue Date
2016-05
Language
English
Article Type
Article
Citation

ELECTROPHORESIS, v.37, no.10, pp.1353 - 1358

ISSN
0173-0835
DOI
10.1002/elps.201600035
URI
http://hdl.handle.net/10203/212494
Appears in Collection
BiS-Journal Papers(저널논문)
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