A compartmental model for the bicoid gradient

Cited 13 time in webofscience Cited 0 time in scopus
  • Hit : 261
  • Download : 0
The anterior region of the Drosophila embryo is patterned by the concentration gradient of the homeodomain transcription factor bicoid (Bcd). The Bcd gradient was the first identified morphogen gradient and continues to be a subject of intense research at multiple levels, from the mechanisms of RNA localization in the oocyte to the evolution of the Bcd-mediated patterning events in multiple Drosophila species. Critical assessment of the mechanisms of the Bcd gradient formation requires biophysical models of the syncytial embryo. Most of the proposed models rely on reaction diffusion equations, but their formulation and applicability at high nuclear densities is a nontrivial task. We propose a straightforward alternative in which the syncytial blastoderm is approximated by a periodic arrangement of well-mixed compartments: a single nucleus and an associated cytoplasmic region. We formulate a compartmental model, constrain its parameters by experimental data, and demonstrate that it provides an adequate description of the Bcd gradient dynamics.
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2010-09
Language
English
Article Type
Article
Keywords

EARLY DROSOPHILA EMBRYO; MORPHOGEN GRADIENT; PROTEIN; ESTABLISHMENT; PROPORTIONS; DIFFUSION; DYNAMICS

Citation

DEVELOPMENTAL BIOLOGY, v.345, no.1, pp.12 - 17

ISSN
0012-1606
DOI
10.1016/j.ydbio.2010.05.491
URI
http://hdl.handle.net/10203/211830
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 13 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0