Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm

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dc.contributor.authorGangadharan, Gireeshko
dc.contributor.authorShin, Jonghanko
dc.contributor.authorKim, Seong-Wookko
dc.contributor.authorKim, Angelako
dc.contributor.authorPaydar, Afshinko
dc.contributor.authorKim, Duk-Sooko
dc.contributor.authorMiyazaki, Taisukeko
dc.contributor.authorWatanabe, Masahikoko
dc.contributor.authorYanagawa, Yuchioko
dc.contributor.authorKim, Jinhyunko
dc.contributor.authorKim, Yeon-Sooko
dc.contributor.authorKim, Daesooko
dc.contributor.authorShin, Hee-Supko
dc.date.accessioned2016-07-07T06:17:01Z-
dc.date.available2016-07-07T06:17:01Z-
dc.date.created2016-06-27-
dc.date.created2016-06-27-
dc.date.issued2016-06-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.113, no.23, pp.6550 - 6555-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10203/209991-
dc.description.abstractExploratory drive is one of the most fundamental emotions, of all organisms, that are evoked by novelty stimulation. Exploratory behavior plays a fundamental role in motivation, learning, and well-being of organisms. Diverse exploratory behaviors have been described, although their heterogeneity is not certain because of the lack of solid experimental evidence for their distinction. Here we present results demonstrating that different neural mechanisms underlie different exploratory behaviors. Localized Ca(v)3.1 knockdown in the medial septum (MS) selectively enhanced object exploration, whereas the null mutant (KO) mice showed enhanced-object exploration as well as open-field exploration. In MS knockdown mice, only type 2 hippocampal theta rhythm was enhanced, whereas both type 1 and type 2 theta rhythm were enhanced in KO mice. This selective effect was accompanied by markedly increased excitability of septo-hippocampal GABAergic projection neurons in the MS lacking T-type Ca2+ channels. Furthermore, optogenetic activation of the septo-hippocampal GABAergic pathway in WT mice also selectively enhanced object exploration behavior and type 2 theta rhythm, whereas inhibition of the same pathway decreased the behavior and the rhythm. These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca2+ channels in the medial septal GABAergic projection neurons in this behavior-
dc.languageEnglish-
dc.publisherNATL ACAD SCIENCES-
dc.subjectCA2+ CHANNELS-
dc.subjectHIPPOCAMPAL-FORMATION-
dc.subjectCALCIUM-CHANNELS-
dc.subjectRATS-
dc.subjectLESIONS-
dc.subjectMICE-
dc.subjectOSCILLATIONS-
dc.subjectNOVELTY-
dc.subjectCORTEX-
dc.subjectBRAIN-
dc.titleMedial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm-
dc.typeArticle-
dc.identifier.wosid000377155400057-
dc.identifier.scopusid2-s2.0-84973392504-
dc.type.rimsART-
dc.citation.volume113-
dc.citation.issue23-
dc.citation.beginningpage6550-
dc.citation.endingpage6555-
dc.citation.publicationnamePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.identifier.doi10.1073/pnas.1605019113-
dc.contributor.localauthorKim, Daesoo-
dc.contributor.nonIdAuthorGangadharan, Gireesh-
dc.contributor.nonIdAuthorShin, Jonghan-
dc.contributor.nonIdAuthorKim, Seong-Wook-
dc.contributor.nonIdAuthorKim, Angela-
dc.contributor.nonIdAuthorPaydar, Afshin-
dc.contributor.nonIdAuthorKim, Duk-Soo-
dc.contributor.nonIdAuthorMiyazaki, Taisuke-
dc.contributor.nonIdAuthorWatanabe, Masahiko-
dc.contributor.nonIdAuthorYanagawa, Yuchio-
dc.contributor.nonIdAuthorKim, Jinhyun-
dc.contributor.nonIdAuthorKim, Yeon-Soo-
dc.contributor.nonIdAuthorShin, Hee-Sup-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorCa(v)3.1 T-type Ca2(+) channel-
dc.subject.keywordAuthorexploratory behaviors-
dc.subject.keywordAuthorhippocampal theta rhythm-
dc.subject.keywordAuthormedial septum-
dc.subject.keywordAuthorsepto-hippocampal-
dc.subject.keywordAuthorGABAergic neurons-
dc.subject.keywordPlusCA2+ CHANNELS-
dc.subject.keywordPlusHIPPOCAMPAL-FORMATION-
dc.subject.keywordPlusCALCIUM-CHANNELS-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusLESIONS-
dc.subject.keywordPlusMICE-
dc.subject.keywordPlusOSCILLATIONS-
dc.subject.keywordPlusNOVELTY-
dc.subject.keywordPlusCORTEX-
dc.subject.keywordPlusBRAIN-
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