Electro-optical Neural Platform Integrated with Nanoplasmonic Inhibition Interface

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Engineering of neural interfaces with rianomaterials for remote manipulation facilitates the development of platforms for the study and treatment of brain disorders, yet extending their capability to inhibiting the electrical activities of unmodified neurons has been difficult. Here we report the development of an electro-optical neural platform integrated with gold nanorods for simultaneous electrical excitation and readout, and photothermal inhibition of neural activities. A monolayer of gold nanorods was placed at the electrode neuron interfaces of a microelectrode array for photothermal stimulation of neural activities. This nanoplasmonic interface interacted well with neurons and metal electrodes without affecting the biological and electrical properties. We demonstrated that spontaneous firing of neurons and their signal propagation along the neurites evoked by electrical stimulation were optically inhibited on this neural platform. We believe that our platform could be an alternative to the optogenetic approach and may ultimately be applied to prosthetic devices based on optical neuromodulation.
Publisher
AMER CHEMICAL SOC
Issue Date
2016-04
Language
English
Article Type
Article
Keywords

DEEP BRAIN-STIMULATION; AXONAL CONDUCTION; CHLORIDE CHANNEL; GOLD NANORODS; LIGHT; OPTOGENETICS; CHANNELRHODOPSIN; NANOPARTICLES; FREQUENCY; NEURONS

Citation

ACS NANO, v.10, no.4, pp.4274 - 4281

ISSN
1936-0851
DOI
10.1021/acsnano.5b07747
URI
http://hdl.handle.net/10203/209219
Appears in Collection
BiS-Journal Papers(저널논문)
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