DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Ho Suk | ko |
dc.contributor.author | Han, Sung Wook | ko |
dc.contributor.author | Kwon, Chang Seob | ko |
dc.contributor.author | Lee, Daeyoup | ko |
dc.date.accessioned | 2016-06-30T00:36:02Z | - |
dc.date.available | 2016-06-30T00:36:02Z | - |
dc.date.created | 2016-02-20 | - |
dc.date.created | 2016-02-20 | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | PROTEIN & CELL, v.7, no.2, pp.100 - 113 | - |
dc.identifier.issn | 1674-800X | - |
dc.identifier.uri | http://hdl.handle.net/10203/208676 | - |
dc.description.abstract | The let-7 miRNA was one of the first miRNAs discovered in the nematode, Caenorhabditis elegans, and its biological functions show a high level of evolutionary conservation from the nematode to the human. Unlike in C. elegans, higher animals have multiple isoforms of let-7 miRNAs; these isoforms share a consensus sequence called the 'seed sequence' and these isoforms are categorized into let-7 miRNA family. The expression of let-7 family is required for developmental timing and tumor suppressor function, but must be suppressed for the self-renewal of stem cells. Therefore, let-7 miRNA biogenesis must be carefully controlled. To generate a let-7 miRNA, a primary transcript is produced by RNA polymerase II and then subsequently processed by Drosha/DGCR8, TUTase, and Dicer. Because dysregulation of let-7 processing is deleterious, biogenesis of let-7 is tightly regulated by cellular factors, such as the RNA binding proteins, LIN28A/B and DIS3L2. In this review, we discuss the biological functions and biogenesis of let-7 miRNAs, focusing on the molecular mechanisms of regulation of let-7 biogenesis in vertebrates, such as the mouse and the human. | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.subject | EMBRYONIC STEM-CELLS | - |
dc.subject | SMALL TEMPORAL RNAS | - |
dc.subject | MICRORNA BIOGENESIS | - |
dc.subject | CAENORHABDITIS-ELEGANS | - |
dc.subject | C-ELEGANS | - |
dc.subject | POSTTRANSCRIPTIONAL REGULATION | - |
dc.subject | NUCLEAR EXPORT | - |
dc.subject | SELF-RENEWAL | - |
dc.subject | HUMAN DICER | - |
dc.subject | DROSOPHILA-MELANOGASTER | - |
dc.title | Biogenesis and regulation of the let-7 miRNAs and their functional implications | - |
dc.type | Article | - |
dc.identifier.wosid | 000372541000004 | - |
dc.identifier.scopusid | 2-s2.0-84957433453 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 100 | - |
dc.citation.endingpage | 113 | - |
dc.citation.publicationname | PROTEIN & CELL | - |
dc.identifier.doi | 10.1007/s13238-015-0212-y | - |
dc.contributor.localauthor | Lee, Daeyoup | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordAuthor | miRNA processing | - |
dc.subject.keywordAuthor | miRNA biogenesis | - |
dc.subject.keywordAuthor | let-7 family | - |
dc.subject.keywordAuthor | TUTase | - |
dc.subject.keywordAuthor | LIN28A/B | - |
dc.subject.keywordPlus | EMBRYONIC STEM-CELLS | - |
dc.subject.keywordPlus | SMALL TEMPORAL RNAS | - |
dc.subject.keywordPlus | MICRORNA BIOGENESIS | - |
dc.subject.keywordPlus | CAENORHABDITIS-ELEGANS | - |
dc.subject.keywordPlus | C-ELEGANS | - |
dc.subject.keywordPlus | POSTTRANSCRIPTIONAL REGULATION | - |
dc.subject.keywordPlus | NUCLEAR EXPORT | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | HUMAN DICER | - |
dc.subject.keywordPlus | DROSOPHILA-MELANOGASTER | - |
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