Axon-First Neuritogenesis on Vertical Nanowires

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In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.
Publisher
AMER CHEMICAL SOC
Issue Date
2016-01
Language
English
Article Type
Article
Keywords

NEURITE OUTGROWTH; HIPPOCAMPAL-NEURONS; ARRAYS; GROWTH; ACCELERATION; CYTOSKELETON; INTERFACES; DYNAMICS; PLATFORM; POLARITY

Citation

NANO LETTERS, v.16, no.1, pp.675 - 680

ISSN
1530-6984
DOI
10.1021/acs.nanolett.5b04458
URI
http://hdl.handle.net/10203/207757
Appears in Collection
BiS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
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