CXXC5 plays a role as a transcription activator for myelin genes on oligodendrocyte differentiation

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Myelination in corpus callosum plays important role for normal brain functions by transferring neurological information between various brain regions. However, the factors controlling expression of myelin genes in myelination are poorly understood. Here, CXXC5, a recently identified protein with CXXC-type zinc finger DNA binding motif, was characterized as a transcriptional activator of major myelin genes. We identified expression of CXXC5 expression was increased by Wnt/-catenin signaling. CXXC5 specifically expressed in the white matter induced expression of myelin genes through the direct binding of CXXC DNA-binding motif of CXXC5 on the MBP promoter. During the differentiation of neural stem cells (NSCs) of CXXC5(-/-) mice, the expressions of myelin genes were simultaneously reduced. The CXXC5(-/-) mice exhibited severely reduction of myelin genes expression in corpus callosum as well as abnormalities in myelin structure. The disrupted structural integrity of myelin in the CXXC5(-/-) mice resulted in reduced electrical conduction amplitudes at corpus callosum. These findings indicate that the regulation of myelin genes expression by CXXC5 is important for forming myelin structure involved with axonal electrical signal transfer in the corpus callosum. GLIA 2016;64:350-36.
Publisher
WILEY-BLACKWELL
Issue Date
2016-03
Language
English
Article Type
Article
Keywords

CENTRAL-NERVOUS-SYSTEM; WNT SIGNALING PATHWAY; WNT/BETA-CATENIN; BASIC-PROTEIN; BIPOLAR DISORDER; CORPUS-CALLOSUM; WHITE-MATTER; MULTIPLE-SCLEROSIS; EXPRESSION; KINASE

Citation

GLIA, v.64, no.3, pp.350 - 362

ISSN
0894-1491
DOI
10.1002/glia.22932
URI
http://hdl.handle.net/10203/207611
Appears in Collection
BS-Journal Papers(저널논문)
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