Interneuron subtypes and Orientation Tuning

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dc.contributor.author이승희ko
dc.contributor.authorKwan, Alex Cko
dc.contributor.authorDan Yangko
dc.date.accessioned2016-04-22T08:16:18Z-
dc.date.available2016-04-22T08:16:18Z-
dc.date.created2016-01-05-
dc.date.issued2014-08-28-
dc.identifier.citation2014 한국계산뇌과학회 학술대회-
dc.identifier.urihttp://hdl.handle.net/10203/205889-
dc.description.abstractarising from B. V. Atallah, W. Bruns, M. Carandini & M. Scanziani 73, 159-170 (2012); N. R. Wilson, C. A. Runyan, F. L. Wang & M. Sur 488, 343-348 10.1038/nature11347(2012); S.-H. Lee et al. 488, 379-383 10.1038/nature11312(2012)Parvalbumin-positive (PV(+)) and somatostatin-positive (SST(+)) interneurons are two principal subtypes of cortical GABAergic neurons that differ in morphology, physiological properties and postsynaptic targeting. Although GABAergic inhibition is known to be crucial for shaping orientation tuning in the visual cortex, it is unclear whether PV(+) and SST(+) interneurons have different roles. Recently, Atallah et al., Wilson et al. and Lee et al. addressed this issue by optogenetically manipulating each interneuron subtype, reaching different conclusions: some investigators found that SST(+) neuron activation sharpens orientation tuning, whereas PV(+) neuron activation has little effect, but others found that activation of PV(+) but not SST(+) interneurons sharpens orientation tuning. To understand the cause for the discrepancy we examined the impact of several experimental differences among the studies-anaesthesia and the level and duration of optogenetic stimulation-and found that the discrepancies can be largely explained by differences in the level and duration of interneuron activation.-
dc.languageEnglish-
dc.publisher한국계산뇌과학회-
dc.titleInterneuron subtypes and Orientation Tuning-
dc.typeConference-
dc.type.rimsCONF-
dc.citation.publicationname2014 한국계산뇌과학회 학술대회-
dc.identifier.conferencecountryKO-
dc.identifier.conferencelocation성신여대 운정캠퍼스-
dc.contributor.localauthor이승희-
dc.contributor.nonIdAuthorKwan, Alex C-
dc.contributor.nonIdAuthorDan Yang-
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BS-Conference Papers(학술회의논문)
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