Inter-Slice Blood Flow and Magnetization Transfer Effects as A New Simultaneous Imaging Strategy

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The recent blood flow and magnetization transfer (MT) technique termed alternate ascending/descending directional navigation (ALADDIN) achieves the contrast using interslice blood flow and MT effects with no separate preparation RF pulse, thereby potentially overcoming limitations of conventional methods. In this study, we examined the signal characteristics of ALADDIN as a simultaneous blood flow and MT imaging strategy, by comparing it with pseudo-continuous ASL (pCASL) and conventional MT asymmetry (MTA) methods, all of which had the same bSSFP readout. Bloch-equation simulations and experiments showed ALADDIN perfusion signals increased with flip angle, whereas MTA signals peaked at flip angle around 45 degrees-60 degrees. ALADDIN provided signals comparable to those of pCASL and conventional MTA methods emulating the first, second, and third prior slices of ALADDIN under the same scan conditions, suggesting ALADDIN signals to be superposition of signals from multiple labeling planes. The quantitative cerebral blood flow signals from a modified continuous ASL model overestimated the perfusion signals compared to those measured with a pulsed ASL method. Simultaneous mapping of blood flow, MTA, and MT ratio in the whole brain is feasible with ALADDIN within a clinically reasonable time, which can potentially help diagnosis of various diseases.
Publisher
PUBLIC LIBRARY SCIENCE
Issue Date
2015-10
Language
English
Article Type
Article
Citation

PLOS ONE, v.10, no.10, pp.e0140560

ISSN
1932-6203
DOI
10.1371/journal.pone.0140560
URI
http://hdl.handle.net/10203/205299
Appears in Collection
BiS-Journal Papers(저널논문)
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