A fluorescent G-quadruplex probe for the assay of base excision repair enzyme activity

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A sensitive and selective assay of uracil DNA glycosylase (UDG) activity is developed by utilizing a G-quadruplex probe incorporating 2-aminopurine (2-AP), based on a novel design that excision reaction promoted by UDG triggers the formation of G-quadruplex structure with significant fluorescence enhancement of 2-AP within the probe.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2015-09
Language
English
Article Type
Article
Citation

CHEMICAL COMMUNICATIONS, v.51, no.72, pp.13744 - 13747

ISSN
1359-7345
DOI
10.1039/c5cc05010c
URI
http://hdl.handle.net/10203/203707
Appears in Collection
CBE-Journal Papers(저널논문)
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