Bacterial polyhydroxyalkanoates

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Polyhydroxyalkanoates (PHAs) are polyesters of hydroxyalkanoates (HAs) synthesized by numerous bacteria as intracellular carbon and energy storage compounds and accumulated as granules in the cytoplasm of cells. More than 80 HAs have been detected as constituents of PHAs, which allows these thermoplastic materials to have various mechanical properties resembling hard crystalline polymer or elastic rubber depending on the incorporated monomer units. Even though PHAs have been recognized as good candidates for biodegradable plastics, their high price compared with conventional plastics has limited their use in a wide range of applications. A number of bacteria including Alcaligenes eutrophus, Alcaligenes latus, Azotobacter vinelandii, methylotrophs, pseudomonads, and recombinant Escherichia coli have been employed for the production of PHAs, and the productivity of greater than 2 g PHA/L/h has been achieved. Recent advances in understanding metabolism, molecular biology, and genetics of the PHA-synthesizing bacteria and cloning of more than 20 different PHA biosynthesis genes allowed construction of various recombinant strains that were able to synthesize polyesters having different monomer units and/or to accumulate much more polymers. Also, genetically engineered plants harboring the bacterial PHA biosynthesis genes are being developed for the economical production of PHAs. Improvements in fermentation/separation technology and the development of bacterial strains or plants that more efficiently synthesize PHAs will bring the costs down to make PHAs competitive with the conventional plastics. (C) 1996 John Wiley & Sons, Inc.
Publisher
WILEY-BLACKWELL
Issue Date
1996-01
Language
English
Article Type
Review
Keywords

POLY-BETA-HYDROXYBUTYRATE; AZOTOBACTER-VINELANDII UWD; FED-BATCH CULTURE; RECOMBINANT ESCHERICHIA-COLI; HIGH-CELL-DENSITY; EXTRACELLULAR POLY(3-HYDROXYBUTYRATE) DEPOLYMERASE; ORGANISM ALCALIGENES-EUTROPHUS; ACETOACETYL-COA REDUCTASE; PSEUDOMONAS-OLEOVORANS; ENZYMATIC DEGRADATION

Citation

BIOTECHNOLOGY AND BIOENGINEERING, v.49, no.1, pp.1 - 14

ISSN
0006-3592
URI
http://hdl.handle.net/10203/20168
Appears in Collection
CBE-Journal Papers(저널논문)
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