Cyclic ADP Ribose-Dependent Ca2+ Release by Group I Metabotropic Glutamate Receptors in Acutely Dissociated Rat Hippocampal Neurons

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dc.contributor.authorSohn, Jong-Wooko
dc.contributor.authorYu, Weon-Jinko
dc.contributor.authorLee, Doyunko
dc.contributor.authorShin, Hee-Supko
dc.contributor.authorLee, Suk-Hoko
dc.contributor.authorHo, Won-Kyungko
dc.date.accessioned2015-11-20T12:44:29Z-
dc.date.available2015-11-20T12:44:29Z-
dc.date.created2014-03-27-
dc.date.created2014-03-27-
dc.date.issued2011-10-
dc.identifier.citationPLOS ONE, v.6, no.10-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10203/201671-
dc.description.abstractGroup I metabotropic glutamate receptors (group I mGluRs; mGluR1 and mGluR5) exert diverse effects on neuronal and synaptic functions, many of which are regulated by intracellular Ca2+. In this study, we characterized the cellular mechanisms underlying Ca2+ mobilization induced by (RS)-3,5-dihydroxyphenylglycine (DHPG; a specific group I mGluR agonist) in the somata of acutely dissociated rat hippocampal neurons using microfluorometry. We found that DHPG activates mGluR5 to mobilize intracellular Ca2+ from ryanodine-sensitive stores via cyclic adenosine diphosphate ribose (cADPR), while the PLC/IP3 signaling pathway was not involved in Ca2+ mobilization. The application of glutamate, which depolarized the membrane potential by 28.5 +/- 4.9 mV (n = 4), led to transient Ca2+ mobilization by mGluR5 and Ca2+ influx through L-type Ca2+ channels. We found no evidence that mGluR5-mediated Ca2+ release and Ca2+ influx through L-type Ca2+ channels interact to generate supralinear Ca2+ transients. Our study provides novel insights into the mechanisms of intracellular Ca2+ mobilization by mGluR5 in the somata of hippocampal neurons.-
dc.languageEnglish-
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.subjectCA1 PYRAMIDAL NEURONS-
dc.subjectLONG-TERM DEPRESSION-
dc.subjectBACKPROPAGATING ACTION-POTENTIALS-
dc.subjectSEA-URCHIN EGGS-
dc.subjectMOLECULAR CHARACTERIZATION-
dc.subjectRYANODINE RECEPTOR-
dc.subjectCALCIUM RELEASE-
dc.subjectCADP-RIBOSE-
dc.subjectEXCITABILITY-
dc.subjectMODULATION-
dc.titleCyclic ADP Ribose-Dependent Ca2+ Release by Group I Metabotropic Glutamate Receptors in Acutely Dissociated Rat Hippocampal Neurons-
dc.typeArticle-
dc.identifier.wosid000296510800063-
dc.identifier.scopusid2-s2.0-80054776011-
dc.type.rimsART-
dc.citation.volume6-
dc.citation.issue10-
dc.citation.publicationnamePLOS ONE-
dc.identifier.doi10.1371/journal.pone.0026625-
dc.contributor.localauthorSohn, Jong-Woo-
dc.contributor.nonIdAuthorYu, Weon-Jin-
dc.contributor.nonIdAuthorLee, Doyun-
dc.contributor.nonIdAuthorShin, Hee-Sup-
dc.contributor.nonIdAuthorLee, Suk-Ho-
dc.contributor.nonIdAuthorHo, Won-Kyung-
dc.type.journalArticleArticle-
dc.subject.keywordPlusCA1 PYRAMIDAL NEURONS-
dc.subject.keywordPlusLONG-TERM DEPRESSION-
dc.subject.keywordPlusBACKPROPAGATING ACTION-POTENTIALS-
dc.subject.keywordPlusSEA-URCHIN EGGS-
dc.subject.keywordPlusMOLECULAR CHARACTERIZATION-
dc.subject.keywordPlusRYANODINE RECEPTOR-
dc.subject.keywordPlusCALCIUM RELEASE-
dc.subject.keywordPlusCADP-RIBOSE-
dc.subject.keywordPlusEXCITABILITY-
dc.subject.keywordPlusMODULATION-
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