Subcellular Neural Probes from Single-Crystal Gold Nanowires

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Size reduction of neural electrodes is essential for improving the functionality of neuroprosthetic devices, developing potent therapies for neurological and neurodegenerative diseases, and long-term brain computer interfaces. Typical neural electrodes are micromanufactured devices with dimensions ranging from tens to hundreds of micrometers. Their further miniaturization is necessary to reduce local tissue damage and chronic immunological reactions of the brain. Here we report the neural electrode with subcellular dimensions based on single-crystalline gold nanowires (NWs) with a diameter of similar to 100 nm. Unique mechanical and electrical properties of defect-free gold NWs enabled their implantation and recording of single neuron-activities in a live mouse brain despite a similar to 50 x reduction of the size compared to the closest analogues. Reduction of electrode dimensions enabled recording of neural activity with improved spatial resolution and differentiation of brain activity in response to different social situations for mice. The successful localization of the epileptic seizure center was also achieved using a multielectrode probe as a demonstration of the diagnostics potential of NW electrodes. This study demonstrated the realism of single-neuron recording using subellular-sized electrodes that may be considered a pivotal point for use in diverse studies of chronic brain diseases.
Publisher
AMER CHEMICAL SOC
Issue Date
2014-08
Language
English
Article Type
Article
Keywords

SILICON MICROELECTRODE ARRAYS; SURFACES; EPILEPSY; CORTEX; AU; DEPOSITION

Citation

ACS NANO, v.8, no.8, pp.8182 - 8189

ISSN
1936-0851
DOI
10.1021/nn5024522
URI
http://hdl.handle.net/10203/201161
Appears in Collection
CH-Journal Papers(저널논문)BiS-Journal Papers(저널논문)
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