Isorhamnetin Protects Human Keratinocytes against Ultraviolet B-Induced Cell Damage

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Isorhamnetin (3-methylquercetin) is a flavonoid derived from the fruits of certain medicinal plants. This study investigated the photoprotective properties of isorhamnetin against cell damage and apoptosis resulting from excessive ultraviolet (UV) B exposure in human HaCaT keratinocytes. Isorhamnetin eliminated UVB-induced intracellular reactive oxygen species (ROS) and attenuated the oxidative modification of DNA, lipids, and proteins in response to UVB radiation. Moreover, isorhamnetin repressed UVB-facilitated programmed cell death in the keratinocytes, as evidenced by a reduction in apoptotic body formation, and nuclear fragmentation. Additionally, isorhamnetin suppressed the ability of UVB light to trigger mitochondrial dysfunction. Taken together, these results indicate that isorhamnetin has the potential to protect human keratinocytes against UVB-induced cell damage and death.
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Issue Date
2015-07
Language
English
Article Type
Article
Citation

BIOMOLECULES & THERAPEUTICS, v.23, no.4, pp.357 - 366

ISSN
1976-9148
DOI
10.4062/biomolther.2015.005
URI
http://hdl.handle.net/10203/200695
Appears in Collection
ME-Journal Papers(저널논문)
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