Since the inception of Globally Asynchronous Locally Synchronous (GALS) VLSI design, GALS has been considered a promising design technique for multi-clock-domain System-on-Chip (SoC). Among the handshake protocols available for SoC design, delay insensitive (DI) handshake protocol is becoming a core technology, since it facilitates robust data transfer regardless of wire delay variation. In this paper, a new data encoding scheme Differential Value Encoding (DVE) is proposed for two-phase 1-of-N DI handshake protocol. Compared with the conventional data encoding method, the proposed scheme effectively reduces the crosstalk effect on wires sending sequentially increasing data patterns, resulting in reduction of the data transfer time. Simulation results with SPEC CPU 2000 benchmarks and sequentially increasing data pattern reveal that the DVE scheme can reduce the crosstalk effect by tens of percentage and significantly decrease the data transfer time.