Characterizations of individual mouse red blood cells parasitized by Babesia microti using 3-D holographic microscopy

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Babesia microti causes "emergency" human babesiosis. However, little is known about the alterations in B. microti invaded red blood cells (Bm-RBCs) at the individual cell level. Through quantitative phase imaging techniques based on laser interferometry, we present the simultaneous measurements of structural, chemical, and mechanical modifications in individual mouse Bm-RBCs. 3-D refractive index maps of individual RBCs and in situ parasite vacuoles are imaged, from which total contents and concentration of dry mass are also precisely quantified. In addition, we examine the dynamic membrane fluctuation of Bm-RBCs, which provide information on cell membrane deformability.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2015-06
Language
English
Article Type
Article
Citation

SCIENTIFIC REPORTS, v.5, pp.10827

ISSN
2045-2322
DOI
10.1038/srep10827
URI
http://hdl.handle.net/10203/199624
Appears in Collection
PH-Journal Papers(저널논문)
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