Synaptic protein degradation underlies destabilization of retrieved fear memory

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Reactivated memory undergoes a rebuilding process that depends on de novo protein synthesis. This suggests that retrieval is dynamic and serves to incorporate new information into preexisting memories. However, little is known about whether or not protein degradation is involved in the reorganization of retrieved memory. We found that postsynaptic proteins were degraded in the hippocampus by polyubiquitination after retrieval of contextual fear memory. Moreover, the infusion of proteasome inhibitor into the CA1 region immediately after retrieval prevented anisomycin- induced memory impairment, as well as the extinction of fear memory. This suggests that ubiquitin- and proteasome-dependent protein degradation underlies destabilization processes after fear memory retrieval. It also provides strong evidence for the existence of reorganization processes whereby preexisting memory is disrupted by protein degradation, and updated memory is reconsolidated by protein synthesis.
Publisher
AMER ASSOC ADVANCEMENT SCIENCE
Issue Date
2008-02
Language
English
Article Type
Article
Citation

SCIENCE, v.319, no.5867, pp.1253 - 1256

ISSN
0036-8075
DOI
10.1126/science.1150541
URI
http://hdl.handle.net/10203/199407
Appears in Collection
BiS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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