DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Do Hyun | ko |
dc.contributor.author | Bae, Chae Yun | ko |
dc.contributor.author | Kwon, Seyong | ko |
dc.contributor.author | Park, Je-Kyun | ko |
dc.date.accessioned | 2015-06-25T06:37:59Z | - |
dc.date.available | 2015-06-25T06:37:59Z | - |
dc.date.created | 2015-06-16 | - |
dc.date.created | 2015-06-16 | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | LAB ON A CHIP, v.15, no.11, pp.2379 - 2387 | - |
dc.identifier.issn | 1473-0197 | - |
dc.identifier.uri | http://hdl.handle.net/10203/199118 | - |
dc.description.abstract | Cell-containing hydrogel modules as cell-hydrogel microunits for creating a physiologically relevant 3D in vivo-like microenvironment with multiple cell types and unique extracellular matrix (ECM) compositions facilitate long-term cell maintenance and bioassays. To date, there have been many important advances in microfluidic bioassays, which incorporate hydrogel scaffolds into surface-accessible microchambers, driven by the strong demand for the application of spatiotemporally defined biochemical stimuli to construct in vivo-like conditions and perform real-time imaging of cell-matrix interactions. In keeping with the trend of fostering collaborations among biologists, clinicians, and microfluidic engineers, it is essential to create a simpler approach for coupling cell-containing hydrogel modules and an automated bioassay platform in a user-friendly format. In this article, we review recent progress in hydrogel-incorporated microfluidics for long-term cell maintenance and discuss some of the simpler and user-friendly 3D bioassay techniques combined with cell-containing hydrogel modules that can be applied to mutually beneficial collaborations with non-engineers. We anticipate that this modular and user-friendly format interfaced with existing laboratory infrastructure will help address several clinical questions in ways that extend well beyond the current 2D cell-culture systems. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | CULTURE | - |
dc.subject | MICROENVIRONMENTS | - |
dc.subject | MICROFIBERS | - |
dc.subject | CHIPS | - |
dc.subject | MODEL | - |
dc.subject | ASSAY | - |
dc.title | User-friendly 3D bioassays with cell-containing hydrogel modules: narrowing the gap between microfluidic bioassays and clinical end-users' needs | - |
dc.type | Article | - |
dc.identifier.wosid | 000354963400004 | - |
dc.identifier.scopusid | 2-s2.0-84930666084 | - |
dc.type.rims | ART | - |
dc.citation.volume | 15 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2379 | - |
dc.citation.endingpage | 2387 | - |
dc.citation.publicationname | LAB ON A CHIP | - |
dc.identifier.doi | 10.1039/c5lc00239g | - |
dc.contributor.localauthor | Park, Je-Kyun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | CULTURE | - |
dc.subject.keywordPlus | MICROENVIRONMENTS | - |
dc.subject.keywordPlus | MICROFIBERS | - |
dc.subject.keywordPlus | CHIPS | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | ASSAY | - |
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