Low-Density Lipoprotein-Mimicking Nanoparticles for Tumor-Targeted Theranostic Applications

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This study introduces multifunctional lipid nanoparticles (LNPs), mimicking the structure and compositions of low-density lipoproteins, for the tumor-targeted co-delivery of anti-cancer drugs and superparamagnetic nanocrystals. Paclitaxel (4.7 wt%) and iron oxide nanocrystals (6.8 wt%, 11 nm in diameter) are co-encapsulated within folate-functionalized LNPs, which contain a cluster of nanocrystals with an overall diameter of about 170 nm and a zeta potential of about -40 mV. The folate-functionalized LNPs enable the targeted detection of MCF-7, human breast adenocarcinoma expressing folate receptors, in T-2-weighted magnetic resonance images as well as the efficient intracellular delivery of paclitaxel. Paclitaxel-free LNPs show no significant cytotoxicity up to 0.2 mg mL(-1), indicating the excellent biocompatibility of the LNPs for intracellular drug delivery applications. The targeted anti-tumor activities of the LNPs in a mouse tumor model suggest that the low-density lipoprotein-mimetic LNPs can be an effective theranostic platform with excellent biocompatibility for the tumor-targeted co-delivery of various anti-cancer agents.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2015-01
Language
English
Article Type
Article
Citation

SMALL, v.11, no.2, pp.222 - 231

ISSN
1613-6810
DOI
10.1002/smll.201303277
URI
http://hdl.handle.net/10203/195266
Appears in Collection
BS-Journal Papers(저널논문)MS-Journal Papers(저널논문)
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