Deoxyribozyme-loaded nano-graphene oxide for simultaneous sensing and silencing of the hepatitis C virus gene in liver cells
The multifunctional DNAzyme (Dz) delivery system is developed based on nano-sized graphene oxide (nGO) for simultaneous detection and knockdown of the target gene. The Dz/nGO complex system allowed convenient monitoring of HCV mRNA in living cells and silencing of the HCV gene expression by Dz-mediated catalytic cleavage concurrently.
- Publisher
- ROYAL SOC CHEMISTRY
- Issue Date
- 2013-10
- Language
- English
- Article Type
- Article
- Keywords
DNA ENZYMES; DELIVERY; DNAZYME; RNA; NANOPARTICLES; REPLICATION; COMPLEX; DRUGS
- Citation
CHEMICAL COMMUNICATIONS, v.49, no.74, pp.8241 - 8243
- ISSN
- 1359-7345
- Appears in Collection
- CH-Journal Papers(저널논문)
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