Neurons on nanometric topographies: insights into neuronal behaviors in vitro

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Topography, the physical characteristics of an environment, is one of the most prominent stimuli neurons can encounter in the body. Many aspects of neurons and neuronal behavior are affected by the size, shape, and pattern of the physical features of the environment. A recent increase in the use of nanometric topographies, due to improved fabrication techniques, has resulted in new findings on neuronal behavior and development. Factors such as neuron adhesion, neurite alignment, and even the rate of neurite formation have all been highlighted through nanotopographies as complex phenomena that are driven by intricate intracellular mechanisms. Nanotopographies are suitable platforms, not only for fundamental studies on neuronal development, but also in practical applications, including multielectrode array devices and neuro-regenerative medicine. We reviewed recent publications that address the effects of nanotopography on neurons and categorized the observed behaviors as adherence, directional guidance, or accelerated outgrowth. We also discussed possible biological mechanisms of the molecular and cellular responses to topography, and suggested future perspectives for this field.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2014-02
Language
English
Article Type
Review
Keywords

SCALE SURFACE TOPOGRAPH; NITRIDE TIN FILMS; HIPPOCAMPAL-NEURONS; NEURITE OUTGROWTH; CONTACT GUIDANCE; CARBON NANOTUBES; POROUS SILICON; ELECTROSPUN NANOFIBERS; AXONAL OUTGROWTH; NEURAL CELLS

Citation

BIOMATERIALS SCIENCE, v.2, no.2, pp.148 - 155

ISSN
2047-4830
DOI
10.1039/c3bm60255a
URI
http://hdl.handle.net/10203/189479
Appears in Collection
CH-Journal Papers(저널논문)
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