Photoluminescent carbon nanotags from harmful cyanobacteria for drug delivery and imaging in cancer cells

Cited 49 time in webofscience Cited 0 time in scopus
  • Hit : 238
  • Download : 141
Using a simple method of mass production of green carbon nanotags (G-tags) from harmful cyanobacteria, we developed an advanced and efficient imaging platform for the purpose of anticancer therapy. Approximately 100 grams of G-tags per 100 kilograms of harmful cyanobacteria were prepared using our eco-friendly approach. The G-tags possess high solubility, excellent photostability, and low cytotoxicity (<1.5 mg/mL for 24 h). Moreover, doxorubicin-conjugated G-tags (T-tags; >0.1 mg/mL) induced death in cancer cells (HepG2 and MCF-7) in-vitro at a higher rate than that of only G-tags while in-vivo mice experiment showed enhanced anticancer efficacy by T-tags at 0.01 mg/mL, indicating that the loaded doxorubicin retains its pharmaceutical activity. The cancer cell uptake and intracellular location of the G- and T-tags were observed. The results indicate that these multifunctional T-tags can deliver doxorubicin to the targeted cancer cells and sense the delivery of doxorubicin by activating the fluorescence of G-tags.
Publisher
NATURE PUBLISHING GROUP
Issue Date
2014-04
Language
English
Article Type
Article
Keywords

MULTIFUNCTIONAL UNIMOLECULAR MICELLES; ONE-STEP SYNTHESIS; IN-VIVO; GOLD NANOPARTICLES; QUANTUM-DOT; NANODOTS; THERAPY; NANOTUBES; GRAPHENE; PLATFORM

Citation

SCIENTIFIC REPORTS, v.4

ISSN
2045-2322
URI
http://hdl.handle.net/10203/188939
Appears in Collection
CBE-Journal Papers(저널논문)
Files in This Item
000334102200018.pdf(1.17 MB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 49 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0