Selective and Sensitive Superoxide Detection with a New Diselenide-Based Molecular Probe in Living Breast Cancer Cells

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A diselenide-based BODIPY probe was prepared; it was found to be sensitive and selective for superoxide in giving [-Se(O)Se(O)-] oxidation. Probing was reversible through the use of biothiols; Se-77 NMR and other types of spectroscopy were employed. Practical medicinal utility was demonstrated in MCF-7/ADR cancer cells.
Publisher
AMER CHEMICAL SOC
Issue Date
2014-01
Language
English
Article Type
Article
Keywords

PHORBOL-MYRISTATE ACETATE; FLUORESCENT-PROBE; OXIDATIVE STRESS; ANTIOXIDANT ACTIVITY; DIARYL DISELENIDES; TURN-ON; CHEMISTRY; BODIPY; OXYGEN; SELENIDE

Citation

ORGANIC LETTERS, v.16, no.2, pp.410 - 412

ISSN
1523-7060
DOI
10.1021/ol4033013
URI
http://hdl.handle.net/10203/187427
Appears in Collection
BS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
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