A novel C-C bond formation by Baylis-Hillman type reaction mediated by SmI2: an effective approach to alpha-hydroxyalkylacrylamide synthesis
alpha-Bromoacrylamides (1) reacted with aldehydes or ketones, in the presence of SmI2 at -78 degrees C in THF, within 5 min to produce Baylis-Hillman type reaction products (2) through an anionic process using vinylsamarium Grignard species in good yields (52-89%).
- Publisher
- ROYAL SOC CHEMISTRY
- Issue Date
- 2000-07
- Language
- English
- Article Type
- Article
- Keywords
LIGAND-ACCELERATED CATALYSIS; SAMARIUM(II) IODIDE; CARBONYL-COMPOUNDS; ASYMMETRIC-SYNTHESIS; RATE ENHANCEMENT; VINYL RADICALS; FIRST-EXAMPLES; DIIODIDE; REAGENTS; CYCLIZATION
- Citation
CHEMICAL COMMUNICATIONS, pp.2005 - 2006
- ISSN
- 1359-7345
- Appears in Collection
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