Organization of the presynaptic active zone by ERC2/CAST1-dependent clustering of the tandem PDZ protein syntenin

Presynaptic active zones contain a cytoskeletal matrix called the CAZ, which is thought to play a critical role in the regulation of active zone formation and neurotransmitter release. Recent studies have identified several CAZ components, but little is known about how they contribute to the molecular organization of active zones. Here, we report a novel PDZ [ postsynaptic density-95/Discs large/zona occludens-1] interaction between the CAZ protein ERC2/CAST1 and the tandem PDZ protein syntenin-1, which is known to associate with diverse synaptic proteins, including glutamate receptor subunits, SynCAM, and beta-neurexin. This interaction promotes the localization of syntenin-1 at presynaptic ERC2 clusters. In addition to the PDZ interaction, multimerization of both ERC2 and syntenin-1 mediates syntenin-1 clustering. These results suggest that ERC2 promotes presynaptic syntenin-1 clustering by two distinct mechanisms and that syntenin-1 may contribute to the molecular organization of active zones by linking ERC2 and other CAZ components to diverse syntenin-1-associated synaptic proteins.
Publisher
SOC NEUROSCIENCE
Issue Date
2006-01
Language
ENG
Keywords

RIM-BINDING PROTEINS; LIPRIN-ALPHA; DIFFERENTIAL REGULATION; MOLECULAR-MECHANISMS; CYTOMATRIX; SYNAPSES; FAMILY; CAST; ASSOCIATION; TERMINALS

Citation

JOURNAL OF NEUROSCIENCE, v.26, no.3, pp.963 - 970

ISSN
0270-6474
DOI
10.1523/JNEUROSCI.4475-05.2006
URI
http://hdl.handle.net/10203/1484
Appears in Collection
BS-Journal Papers(저널논문)
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