Poly[lactic-co-(glycolic acid)]-Grafted Hyaluronic Acid Copolymer Micelle Nanoparticles for Target-Specific Delivery of Doxorubicin

PLGA-grafted HA copolymers were synthesized and utilized as target specific micelle carriers for DOX. For grafting hydrophobic PLGA chains onto the backbone of hydrophilic HA, HA was solubilized in an anhydrous DMSO by nano-complexing with dimethoxy-PEG. The carboxylic groups of HA were chemically grafted with PLGA, producing HA-g-PLGA copolymers. Resultant HA-g-PLGA self-assembled in aqueous solution to form multi-cored micellar aggregates and DOX was encapsulated during the self-assembly. DOX-londed HA-g-PLGA micelle nanoparticles exhibited higher cellular uptake and greater cytotoxicity than free DOX for HCT-116 cells that over-expressed HA receptor, suggesting that they were taken up by the cells via HA receptor-mediated endocytosis.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2009-04
Language
ENG
Keywords

DRUG-DELIVERY; INTRACELLULAR DELIVERY; ANTITUMOR-ACTIVITY; BLOCK-COPOLYMERS; DERIVATIVES; INHIBITION; HYDROGELS; NANOGELS; GLYCOL); CELLS

Citation

MACROMOLECULAR BIOSCIENCE, v.9, no.4, pp.336 - 342

ISSN
1616-5187
DOI
10.1002/mabi.200800229
URI
http://hdl.handle.net/10203/13289
Appears in Collection
BS-Journal Papers(저널논문)
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