Surface engineered and drug releasing pre-fabricated scaffolds for tissue engineering

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A wide range of polymeric scaffolds have been intensively studied for use as implantable and temporal devices in tissue engineering. Biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, and differentiation, and guidance for cellular in-growth from host tissue. A variety of natural and synthetic polymeric scaffolds can be :fabricated in the form of a solid foam, nanofibrous matrix, microsphere, or hydrogel. Biodegradable porous scaffolds can be surface engineered to provide an extracellular matrix mimicking environment for better cell adhesion and tissue in-growth. Furthermore, scaffolds can be designed to :release bioactive molecules, such as growth factors, DNA, or drugs, in a sustained manner to facilitate tissue regeneration. This paper reviews the current status of surface engineered and drug releasing scaffolds for tissue engineering. (c) 2007 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2007-05
Language
English
Article Type
Review
Keywords

FIBROBLAST-GROWTH-FACTOR; BIODEGRADABLE POLYMER SCAFFOLDS; INDUCED PHASE-SEPARATION; MESENCHYMAL STEM-CELLS; BONE MORPHOGENETIC PROTEIN-2; FOAMING/SALT-LEACHING METHOD; ADHESIVE RGD PEPTIDE; IN-VIVO; SUSTAINED-RELEASE; FACTOR DELIVERY

Citation

ADVANCED DRUG DELIVERY REVIEWS, v.59, no.4-5, pp.249 - 262

ISSN
0169-409X
DOI
10.1016/j.addr.2007.03.015
URI
http://hdl.handle.net/10203/12372
Appears in Collection
NT-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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