A recently developed semi-active control system employing magneto-rheological (MR) fluid dampers is applied to vibration control of a wind excited tall building. The semi-active control system with MR fluid dampers appears to have the reliability of passive control devices and the adaptability of fully active control systems. The system requires only small power source, which is critical during severe events, when the main power source may fail. Numerical simulation studies are performed to demonstrate the efficiency of the MR dampers on the third ASCE benchmark problem. Multiple MR dampers are assumed to be installed in the 76-story building. Genetic algorithm is applied to determine the optimal locations and capacities of the MR dampers. Clipped optimal controller is designed to control the MR dampers based on the acceleration feedback. To verify the robustness with respect to the variation of the external wind force, several cases with different wind forces are considered in the numerical simulation. Simulation results show that the semi-actively controlled MR dampers can effectively reduce both the peak and RMS responses the tall building under various wind force conditions. The control performance of the MR dampers for wind is found to be fairly similar to the performance of an active tuned mass damper.