DSpace Community: KAIST College of Natural SciencesKAIST College of Natural Scienceshttp://hdl.handle.net/10203/112019-10-10T20:26:41Z2019-10-10T20:26:41Zl-adic étale cohomology of Shimura varieties of Hodge type with non-trivial coefficientsHamacher, PaulKim, Wansuhttp://hdl.handle.net/10203/2518972019-03-19T02:01:12ZTitle: l-adic étale cohomology of Shimura varieties of Hodge type with non-trivial coefficients
Authors: Hamacher, Paul; Kim, WansuStructural diversity and flexibility of diabodiesKwon, Na-YoungKim, YoungjinLee, Jie-Ohhttp://hdl.handle.net/10203/2504792019-02-26T11:22:43ZTitle: Structural diversity and flexibility of diabodies
Authors: Kwon, Na-Young; Kim, Youngjin; Lee, Jie-Oh
Abstract: Diabodies are bispecific antibody fragments that have two antigen binding Fv domains. They are unique among hundreds of different formats of bispecific antibodies because they are small and rigid enough to be crystallized. Diabodies are generated by connecting variable regions of heavy and light chains by a peptide linker. Because of the short length of the linker, intramolecular association of the variable regions is not allowed. Instead, the variable regions from the different peptide chains associate together, forming a dimeric complex with two antigen binding sites. Previous crystallographic studies of diabodies demonstrate the extraordinary structural diversity of diabodies. They have also shown that the relative orientation and interaction of the two Fv domains in diabodies have substantial flexibility due to instability of the Fv interface. Introduction of site specific mutations and disulfide bridges can reduce flexibility and therefore increase rigidity and predictability of the diabody structures. These stabilized diabodies will be useful for future application to structural biology and protein nanotechnology.A logarithmic chemotaxis model featuring global existence and aggregationDesvillettes, LaurentKim, Yong-JungTrescases, ArianeYoon, Changwookhttp://hdl.handle.net/10203/2643212019-08-20T05:20:03Z2019-12-01T00:00:00ZTitle: A logarithmic chemotaxis model featuring global existence and aggregation
Authors: Desvillettes, Laurent; Kim, Yong-Jung; Trescases, Ariane; Yoon, Changwook
Abstract: The global existence of a chemotaxis model for cell aggregation phenomenon is obtained. The model system belongs to the class of logarithmic models and takes a Fokker-Planck type diffusion for the equation of cell density. We show that weak solutions exist globally in time in dimensions n is an element of {1, 2, 3} and for large initial data. The proof covers the parameter regimes that constant steady states are linearly stable. It also partially covers the other parameter regimes that constant steady states are unstable. We also find the sharp instability condition of constant steady states and provide numerical simulations which illustrate the formation of aggregation patterns. (C) 2019 Elsevier Ltd. All rights reserved.2019-12-01T00:00:00ZThe transcendence of zeros of canonical basis elements of the space of weakly holomorphic modular forms for Gamma(0)(2)Choi, SoYoungIm, Bo-Haehttp://hdl.handle.net/10203/2643232019-08-22T03:20:06Z2019-11-01T00:00:00ZTitle: The transcendence of zeros of canonical basis elements of the space of weakly holomorphic modular forms for Gamma(0)(2)
Authors: Choi, SoYoung; Im, Bo-Hae
Abstract: We consider the canonical basis elements f(k,m)(epsilon) for the space of weakly holomorphic modular forms of weight k for the Hecke congruence group Gamma(0)(2) and we prove that for all m >= c(k) for some constant c(k), if z(0) in a fundamen- tal domain for Gamma(0)(2) is a zero of f(k,m)(epsilon), then either z(0) is in {i/root 2, - 1/2 + i/2, 1/2 + i/2, -1+i root 7/4, 1+i root 7/4} or z(0) is transcendental. (C) 2019 Elsevier Inc. All rights reserved.2019-11-01T00:00:00Z